Constructivist Stakian Multicase Study: Methodological Issues Encountered in Cross-Cultural Palliative Care Research

Case study research facilitates the in-depth, real-life exploration of complex phenomena from multiple perspectives.It is a well-established approach to deal with the complexities involved in palliative care research.Case studies are not aligned to a single epistemological paradigm but are defined by the identification of the case to be studied.Thi

read more

Managing Benign and Malignant Oral Lesions with Carbon Dioxide Laser: Indications, Techniques, and Outcomes for Outpatient Surgery

Abstract Purpose Because of its affinity for water-based tissues, carbon dioxide (CO2) laser has become an instrument of choice for treating oral mucosa conditions, ranging from inflammatory to malignant lesions.The aim of this work is to systematically evaluate the outcomes of laser surgery over a wide range of lesions, while providing a solid and

read more

Microglial AKAP8L: a key mediator in diabetes-associated cognitive impairment via autophagy inhibition and neuroinflammation triggering

Abstract Background Diabetes-associated cognitive impairment (DACI) poses a significant challenge to the self-management of diabetes, markedly elevating the risk of adverse complications.A burgeoning body of evidence implicates microglia as a central player in the pathogenesis of DACI.Methods We utilized proteomics to identify potential biomarkers

read more